Clinical BMI Studies

Most clinical studies that apply and test brain-machine interfaces are focusing on restoration of movement or communication. Besides these important fields, also other applications are now increasingly tested, e.g. in the context of neuropsychiatric disorders, e.g. in depression, autism or Alzheimer’s disease.

Restoration of Movement

ALS (Amyotrophic Lateral Sclerosis)

Study	Status
NeuroCognitive Communicator: Safety Study (NCC-1701) Ottawa Hospital Research Institute	Not yet recruiting
Restore Motor Function Through Robotic Arm Exoskeleton and Brain Computer Interface (REMAP) University of Aarhus	Enrolling by invitation
EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS) (BCI) Drexel University College of Medicine	Completed (December 2016)
An In-home Study of Brain Computer Interfaces University of Michigan	Completed (May 2011)
A P300 Brain Computer Interface Keyboard to Control Assistive Technology For Use by People With Amyotrophic Lateral Sclerosis University of Michigan	Completed (August 2010)
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis University of Pittsburgh	Completed (April 2015)
P300 Brain Computer Interface Keyboard to Operate Assistive Technology University of Michigan	Completed (May 2012)
A P300 Brain Computer Interface to Operate Power Wheelchair Tilt University of Michigan	Completed (August 2010)
A Clinical Demonstration of EEG Brain-computer Interface for ALS Patients VA Medical Center, Cleveland	Completed (August 2014)

Tetraplegia / Quadriplegia

Study	Status
An Early Feasibility Study of the ReHAB System (ReHAB) University Hospitals Cleveland Medical Center	Not yet recruiting
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Massachusetts General Hospital	Recruiting
Brain Computer Interface: Neuroprosthetic Control of a Motorized Exoskeleton (BCI) University Hospital, Grenoble	Recruiting
Providing Closed Loop Cortical Control of Extracorporeal Devices to Patients With Quadriplegia University of Southern California Rancho Los Amigos National Rehabilitation Center	Recruiting
Brain Machine Interface (BMI) in Subjects Living With Quadriplegia (BMI) University of Miami	Active, not recruiting
Microelectrode Brain-Machine Interface for Individuals With Tetraplegia University of Pittsburgh	Recruiting
Cortical Recording and Stimulating Array Brain-Machine Interface University of Pittsburgh	Recruiting
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Masachusetts General Hospital	Recruiting
Providing Brain Control of Extracorporeal Devices to Patients With Quadriplegia Caliofornia Institute of Technology, University of Southern California, Rancho Los Amigos National Rehabilitation Center	Completed (January 2019)
Providing Closed Loop Cortical Control of Extracorporeal Devices to Patients With Quadriplegia Caliofornia Institute of Technology, University of Southern California, Rancho Los Amigos National Rehabilitation Center	Recruiting
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis University of Pittsburgh	Completed (April 2015)

Stroke

Study	Status
Stroke Rehabilitation Using BCI Technology University of Wisconsin, Madison	Recruiting
BCI-controlled NMES in Subacute Stroke University Hospital, Geneva	Recruiting
Assistive Soft Robotic Glove Intervention Using Brain-Computer Interface for Elderly Stroke Patients National University Hospital, Singapore	Active, not recruiting
Chronic Stroke Rehabilitation With Contralesional Brain-Computer Interface Washington University School of Medicine	Recruiting
Treatment of Chronic Stroke With IpsiHand Washington University School of Medicine	Completed (November 2015)
Neurofeedback for Upper-limb Recovery After Stroke(NeuroFB-AVC) Rennes University Hospital	Recruiting
A Study of Neurostyle Brain Exercise Therapy Towards Enhanced Recovery (nBETTER) for Stroke(nBETTER) Tan Tock Seng Hospital	Completed (August 2017)
Effect of Brain-Computer Interfaced-Assisted Motor Imagery for Gait Retraining in Stroke Patients National University Hospital, Singapore	Completed (January 2018)
Efficacy of Hand Exoskeleton Controlled by BCI in Post Stroke Patients Russian Academy of Medical Sciences	Completed (September 2017)
Refinement and Clinical Evaluation of the H-Man for Arm Rehabilitation After Stroke Tan Tock Seng Hospital	Recruiting
Brain Machine Interface Control of an Robotic Exoskeleton in Training Upper Extremity Functions in Stroke William Marsh Rice University, Univerity of Houston, The University of Texas Health Science Center (Houston), The Methodist Hospital System	Recruiting
Human-Machine System for the H2 Lower Limb Exoskeleton University of Houston, TIRR Memorial Hermann Hospital, Spanish Research Council	Unknown
Non-Invasive Brain Signal Training to Induce Motor Control Recovery After Stroke Malcom Randall VA Medical Center	Completed (June 2016)
A Brain Centered Neuroengineering Approach for Motor Recovery After Stroke: Combined rTMS and BCI Training University of Minnesota – Clinical and Translational Science Institute	Completed (June 2017)
Brain Computer Interface（BCI) System for Stroke Rehabilitation Chinese University oh Hong Kong	Completed (June 2017)
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Masachusetts General Hospital	Recruiting
Cortical Recording and Stimulating Array Brain-Machine Interface University of Pittsburgh	Recruiting
Wireless Brain-computer-interface-controlled Neurorehabilitation System for Patients With Stroke Department of Physical Medicine and Rehabilitation, China Medical University Hospital	Unknown
BCI Post-stroke Neurorehabilitation CHRU Montpellier, Lapeyronie // Euromov-M2H, Montpellier University	Completed (October 2015)
Neurofeedback Training of Alpha-band Coherence After Stroke University of Geneva	Completed (June 2016)
Combined Transcranial Direct Current Stimulation and Motor Imagery-based Robotic Arm Training for Stroke Rehabilitation National University Hospital, Singapore	Completed (January 2014)
Brain Training System Using Electroencephalography (EEG) for Neurorehabilitation of Hand Function After Stroke Chinese University of Hong Kong	Unknown
Evaluating Human-Machine Interfaces in a Robotic Thumb Orthosis Wyss Institute at Harvard Univerity, Children’s Hospital Boston	Active, not recruiting
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis University of Pittsburgh	Completed (April 2015)
Brain Computer Interface (BCI) Technology for Stroke Hand Rehabilitation Tan Tock Seng Hospital	Completed (June 2013)
Brain Computer Interface (BCI) Based Robotic Rehabilitation for Stroke National Neurosience Institute	Unknown
Moving a Paralyzed Hand Through Use of a Brain-Computer Interface National Institute of Neurological Disorders and Stroke (NINDS)	Completed (July 2013)

Restoration of Communication

ALS (Amyotrophic Lateral Sclerosis)

Study	Status
First Study With a Brain Implant to Help Locked-in Patients Communicate at Home (UNP) UMC Utrecht	Recruiting
Brain Computer Interface Complete locked-in State Communication. University Hospital Tuebingen	Recruiting
An In-home Study of Brain Computer Interfaces University of Michigan	Completed (May 2011)
Communication by Brain – Computer Interface in Amyotrophic Lateral Sclerosis:Feasibility Study Centre Hospitalier Universitaire de Nice	Unknown

Tetraplegia / Quadriplegia

Study	Status
Brain Implant for Neural Control of a Computer California Institute of Technology	Recruiting
Robust Intelligent Keyboard for Quadraplegic Patients University of Versailles	Recruiting
Brain Computer Interface for Communication in ICU: a Feasibility Study University of Versailles	Completed (May 2012)

Other

Alzheimer´s Disease

Study	Status
Neurofeedback in Alzheimer’s Disease Oregon Health and Science University	Not yet recruiting
Brain-Computer Interface System for Training Memory and Attention in Elderly Duke-NUS Graduate Medical School, Duke University	Completed (June 2017)
Effectiveness of a Brain-Computer Interface Based System for Cognitive Enhancement in the Normal Elderly Duke-NUS Graduate Medical School	Completed (April 2014)

Autism

Study	Status
Brain-Computer Interface-based Programme for the Treatment of ASD/ADHD (ASDBCI) Duke-NUS Graduate Medical School	Recruiting
BCI (Brain Computer Interface) Intervention in Autism IBILI – Institute for Biomedical Imaging in Life Sciences	Completed (September 2018)
Rt-fMRI NF Intervention Study in ASD IBILI – Institute for Biomedical Imaging in Life Sciences	Completed (September 2018)

Depressive Disorders

Study	Status
Affect Regulation Based on Brain-computer Interface Towards Treatment for Depression Institute of Mental Health, Singapore	Completed (September 2018)
Symptom Based Treatment Affects Brain Plasticity – Cognitive Training in Patients With Affective Symptoms (APIC-II) RWTH Aachen University	Not yet recruiting
A Feasibility Study to Evaluate Safety and Initial Effectiveness of ExAblate Transcranial MR Guided Focused Ultrasound for Bilateral Anterior Capsulotomy in the Treatment of Medication-Refractory MDD Yonsei University	Completed (July 2018)

Fibromyalgie

Study	Status
Neurofeedback for Fibromyalgia Institute of Pain Mecine, Tel Aviv Sourasky Medical Center	Unknown

Epilepsy

Study	Status
Brain Computer Interfaces for Functional Recovery From Brain Injury University of Washington	Recruiting