Clinical BMI Studies

Most clinical studies that apply and test brain-machine interfaces are focusing on restoration of movement or communication. Besides these important fields, also other applications are now increasingly tested, e.g. in the context of neuropsychiatric disorders, e.g. in depression, autism or Alzheimer’s disease.

Restoration of Movement

ALS (Amyotrophic Lateral Sclerosis)

Study	Status
EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS) (BCI) Drexel University College of Medicine	Recruiting
An In-home Study of Brain Computer Interfaces University of Michigan	Completed (May 2011)
A P300 Brain Computer Interface Keyboard to Control Assistive Technology For Use by People With Amyotrophic Lateral Sclerosis University of Michigan	Completed (June 2015)
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis University of Pittsburgh	Completed (June 2015)
P300 Brain Computer Interface Keyboard to Operate Assistive Technology University of Michigan	Completed (May 2015)
A P300 Brain Computer Interface to Operate Power Wheelchair Tilt University of Michigan	Completed (Juni 2014)
A Clinical Demonstration of EEG Brain-computer Interface for ALS Patients VA Medical Center, Cleveland	Completed, has results (January 2015)

Tetraplegia / Quadriplegia

Study	Status
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Massachusetts General Hospital	Recruiting
Brain Computer Interface: Neuroprosthetic Control of a Motorized Exoskeleton (BCI) University Hospital, Grenoble	Recruiting
Providing Closed Loop Cortical Control of Extracorporeal Devices to Patients With Quadriplegia University of Southern California Rancho Los Amigos National Rehabilitation Center	Recruiting
Brain Machine Interface (BMI) in Subjects Living With Quadriplegia (BMI) University of Miami	Recruiting
Microelectrode Brain-Machine Interface for Individuals With Tetraplegia University of Pittsburgh	Recruiting
Cortical Recording and Stimulating Array Brain-Machine Interface University of Pittsburgh	Recruiting
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Masachusetts General Hospital	Recruiting
Providing Brain Control of Extracorporeal Devices to Patients With Quadriplegia Caliofornia Institute of Technology, University of Southern California, Rancho Los Amigos National Rehabilitation Center	Active, not recruiting
Providing Closed Loop Cortical Control of Extracorporeal Devices to Patients With Quadriplegia Caliofornia Institute of Technology, University of Southern California, Rancho Los Amigos National Rehabilitation Center	Recruiting
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis University of Pittsburgh	Completed (June 2015)

Stroke

Study	Status
Effect of Brain-Computer Interfaced-Assisted Motor Imagery for Gait Retraining in Stroke Patients National University Hospital, Singapore	Not yet recruiting
Efficacy of Hand Exoskeleton Controlled by BCI in Post Stroke Patients Russian Academy of Medical Sciences	Not yet recruiting
Refinement and Clinical Evaluation of the H-Man for Arm Rehabilitation After Stroke Tan Tock Seng Hospital	Recruiting
Brain Machine Interface Control of an Robotic Exoskeleton in Training Upper Extremity Functions in Stroke William Marsh Rice University, Univerity of Houston, The University of Texas Health Science Center (Houston), The Methodist Hospital System	Recruiting
Human-Machine System for the H2 Lower Limb Exoskeleton University of Houston, TIRR Memorial Hermann Hospital, Spanish Research Council	Recruiting
Non-Invasive Brain Signal Training to Induce Motor Control Recovery After Stroke Malcom Randall VA Medical Center	Completed (June 2016)
A Brain Centered Neuroengineering Approach for Motor Recovery After Stroke: Combined rTMS and BCI Training University of Minnesota – Clinical and Translational Science Institute	Active, not recruiting
Brain Computer Interface（BCI） System for Stroke Rehabilitation Chinese University oh Hong Kong	Recruiting
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Masachusetts General Hospital	Recruiting
Cortical Recording and Stimulating Array Brain-Machine Interface University of Pittsburgh	Recruiting
Wireless Brain-computer-interface-controlled Neurorehabilitation System for Patients With Stroke Department of Physical Medicine and Rehabilitation, China Medical University Hospital	Recruiting
BCI Post-stroke Neurorehabilitation CHRU Montpellier, Lapeyronie // Euromov-M2H, Montpellier University	Completed (October 2015)
Neurofeedback Training of Alpha-band Coherence After Stroke University of Geneva	Completed (June 2016)
Combined Transcranial Direct Current Stimulation and Motor Imagery-based Robotic Arm Training for Stroke Rehabilitation National University Hospital, Singapore	Completed (January 2014)
Brain Training System Using Electroencephalography (EEG) for Neurorehabilitation of Hand Function After Stroke Chinese University of Hong Kong	Recruiting
Evaluating Human-Machine Interfaces in a Robotic Thumb Orthosis Wyss Institute at Harvard Univerity, Children’s Hospital Boston	Active, not recruiting
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis University of Pittsburgh	Completed (June 2015)
Brain Computer Interface (BCI) Technology for Stroke Hand Rehabilitation Tan Tock Seng Hospital	Completed (March 2014)
Brain Computer Interface (BCI) Based Robotic Rehabilitation for Stroke National Neurosience Institute	Unknown
Moving a Paralyzed Hand Through Use of a Brain-Computer Interface National Institute of Neurological Disorders and Stroke (NINDS)	Terminated (July 2013)

Restoration of Communication

ALS (Amyotrophic Lateral Sclerosis)

Study	Status
An In-home Study of Brain Computer Interfaces University of Michigan	Completed (2011)
Communication by Brain – Computer Interface in Amyotrophic Lateral Sclerosis:Feasibility Study Centre Hospitalier Universitaire de Nice	Unknown

Tetraplegia / Quadriplegia

Study	Status
Brain Implant for Neural Control of a Computer California Institute of Technology	Recruiting
Robust Intelligent Keyboard for Quadraplegic Patients University of Versailles	Completed (May 2014)
Brain Computer Interface for Communication in ICU: a Feasibility Study University of Versailles	Completed (May 2012)

Other

Alzheimer´s Disease

Study	Status
Brain-Computer Interface System for Training Memory and Attention in Elderly Duke-NUS Graduate Medical School, Duke University	Recruiting
Effectiveness of a Brain-Computer Interface Based System for Cognitive Enhancement in the Normal Elderly Duke-NUS Graduate Medical School	Completed (July 2014)

Autism

Study	Status
BCI (Brain Computer Interface) Intervention in Autism IBILI – Institute for Biomedical Imaging in Life Sciences	Enrolling by invitation
Rt-fMRI NF Intervention Study in ASD IBILI – Institute for Biomedical Imaging in Life Sciences	Enrolling by invitation

Depressive Disorders

Study	Status
A Feasibility Study to Evaluate Safety and Initial Effectiveness of ExAblate Transcranial MR Guided Focused Ultrasound for Bilateral Anterior Capsulotomy in the Treatment of Medication-Refractory MDD Yonsei University	Recruiting

Fibromyalgie

Study	Status
Neurofeedback for Fibromyalgia Institute of Pain Mecine, Tel Aviv Sourasky Medical Center	Unknown

Epilepsy

Study	Status
Brain Computer Interfaces for Functional Recovery From Brain Injury University of Washington	Recruiting