Clinical BMI Studies

Most clinical studies that apply and test brain-machine interfaces are focusing on restoration of movement or communication. Besides these important fields, also other applications are now increasingly tested, e.g. in the context of neuropsychiatric disorders, e.g. in depression, autism or Alzheimer’s disease.

Restoration of Movement

ALS (Amyotrophic Lateral Sclerosis)

Study

Status

EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS) (BCI)
Drexel University College of Medicine

Recruiting

An In-home Study of Brain Computer Interfaces
University of Michigan

Completed (May 2011)

A P300 Brain Computer Interface Keyboard to Control Assistive Technology For Use by People With Amyotrophic Lateral Sclerosis
University of Michigan

Completed (June 2015)

ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis
University of Pittsburgh

Completed (June 2015)

P300 Brain Computer Interface Keyboard to Operate Assistive Technology
University of Michigan

Completed (May 2015)

A P300 Brain Computer Interface to Operate Power Wheelchair Tilt
University of Michigan

Completed (Juni 2014)

A Clinical Demonstration of EEG Brain-computer Interface for ALS Patients
VA Medical Center, Cleveland

Completed, has results (January 2015)

Tetraplegia / Quadriplegia

Study

Status

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Massachusetts General Hospital

Recruiting

Brain Computer Interface: Neuroprosthetic Control of a Motorized Exoskeleton (BCI)
University Hospital, Grenoble

Recruiting

Providing Closed Loop Cortical Control of Extracorporeal Devices to Patients With Quadriplegia
University of Southern California
Rancho Los Amigos National Rehabilitation Center

Recruiting

Brain Machine Interface (BMI) in Subjects Living With Quadriplegia (BMI)
University of Miami

Recruiting

Microelectrode Brain-Machine Interface for Individuals With Tetraplegia
University of Pittsburgh

Recruiting

Cortical Recording and Stimulating Array Brain-Machine Interface
University of Pittsburgh

Recruiting

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Masachusetts General Hospital

Recruiting

Providing Brain Control of Extracorporeal Devices to Patients With Quadriplegia
Caliofornia Institute of Technology, University of Southern California, Rancho Los Amigos National Rehabilitation Center

Active, not recruiting

Providing Closed Loop Cortical Control of Extracorporeal Devices to Patients With Quadriplegia
Caliofornia Institute of Technology, University of Southern California, Rancho Los Amigos National Rehabilitation Center

Recruiting

ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis
University of Pittsburgh

 Completed (June 2015)

Stroke

Study

Status

Effect of Brain-Computer Interfaced-Assisted Motor Imagery for Gait Retraining in Stroke Patients
National University Hospital, Singapore

Not yet recruiting

Efficacy of Hand Exoskeleton Controlled by BCI in Post Stroke Patients
Russian Academy of Medical Sciences

Not yet recruiting

 Refinement and Clinical Evaluation of the H-Man for Arm Rehabilitation After Stroke
Tan Tock Seng Hospital

Recruiting

Brain Machine Interface Control of an Robotic Exoskeleton in Training Upper Extremity Functions in Stroke
William Marsh Rice University, Univerity of Houston, The University of Texas Health Science Center (Houston), The Methodist Hospital System

Recruiting

Human-Machine System for the H2 Lower Limb Exoskeleton
University of Houston, TIRR Memorial Hermann Hospital, Spanish Research Council

Recruiting

Non-Invasive Brain Signal Training to Induce Motor Control Recovery After Stroke
Malcom Randall VA Medical Center

Completed (June 2016)

A Brain Centered Neuroengineering Approach for Motor Recovery After Stroke: Combined rTMS and BCI Training
University of Minnesota – Clinical and Translational Science Institute

Active, not recruiting

Brain Computer InterfaceBCI) System for Stroke Rehabilitation
Chinese University oh Hong Kong

Recruiting

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Masachusetts General Hospital

Recruiting

Cortical Recording and Stimulating Array Brain-Machine Interface
University of Pittsburgh

Recruiting

Wireless Brain-computer-interface-controlled Neurorehabilitation System for Patients With Stroke
Department of Physical Medicine and Rehabilitation, China Medical University Hospital

Recruiting

BCI Post-stroke Neurorehabilitation
CHRU Montpellier, Lapeyronie // Euromov-M2H, Montpellier University

Completed (October 2015)

Neurofeedback Training of Alpha-band Coherence After Stroke
University of Geneva

Completed (June 2016)

Combined Transcranial Direct Current Stimulation and Motor Imagery-based Robotic Arm Training for Stroke Rehabilitation
National University Hospital, Singapore

Completed (January 2014)

Brain Training System Using Electroencephalography (EEG) for Neurorehabilitation of Hand Function After Stroke
Chinese University of Hong Kong

Recruiting

Evaluating Human-Machine Interfaces in a Robotic Thumb Orthosis
Wyss Institute at Harvard Univerity, Children’s Hospital Boston

Active, not recruiting

ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis
University of Pittsburgh

Completed (June 2015)

Brain Computer Interface (BCI) Technology for Stroke Hand Rehabilitation
Tan Tock Seng Hospital

Completed (March 2014)

Brain Computer Interface (BCI) Based Robotic Rehabilitation for Stroke
National Neurosience Institute

Unknown

Moving a Paralyzed Hand Through Use of a Brain-Computer Interface
National Institute of Neurological Disorders and Stroke (NINDS)

Terminated (July 2013)

Restoration of Communication

ALS (Amyotrophic Lateral Sclerosis)

Study Status
An In-home Study of Brain Computer Interfaces
University of Michigan
Completed (2011)

Communication by Brain – Computer Interface in Amyotrophic Lateral Sclerosis:Feasibility Study
Centre Hospitalier Universitaire de Nice

Unknown

Tetraplegia / Quadriplegia

Study Status

Brain Implant for Neural Control of a Computer
California Institute of Technology

Recruiting

Robust Intelligent Keyboard for Quadraplegic Patients
University of Versailles

Completed (May 2014)

Brain Computer Interface for Communication in ICU: a Feasibility Study
University of Versailles

Completed (May 2012)

Other

Alzheimer´s Disease

Study Status
Brain-Computer Interface System for Training Memory and Attention in Elderly
Duke-NUS Graduate Medical School, Duke University
Recruiting
Effectiveness of a Brain-Computer Interface Based System for Cognitive Enhancement in the Normal Elderly
Duke-NUS Graduate Medical School
Completed (July 2014)

Autism

Study Status
BCI (Brain Computer Interface) Intervention in Autism
IBILI – Institute for Biomedical Imaging in Life Sciences
Enrolling by invitation
Rt-fMRI NF Intervention Study in ASD
IBILI – Institute for Biomedical Imaging in Life Sciences
Enrolling by invitation

Depressive Disorders

Study Status
A Feasibility Study to Evaluate Safety and Initial Effectiveness of ExAblate Transcranial MR Guided Focused Ultrasound for Bilateral Anterior Capsulotomy in the Treatment of Medication-Refractory MDD
Yonsei University
Recruiting

Fibromyalgie

Study Status
Neurofeedback for Fibromyalgia
Institute of Pain Mecine, Tel Aviv Sourasky Medical Center
Unknown

Epilepsy

Study Status
Brain Computer Interfaces for Functional Recovery From Brain Injury
University of Washington
Recruiting